The risk of acquiring autologous stem cell graft
According to recent research, this risk is “Fewer than 1 in 2500″. For a child in whom there is a direct family history of Sickle cell disease, Fanconi or Diamond-Blackfan anaemia and some inherited Leukaemias, the risk of a sibling or child requiring a stem cell transplant may be much higher depending on a number of factors. For a healthy family without a dominantly inherited malignancy or condition of this type the risk quoted may in fact be far less than 1 in 20,000 as there have only been 4 or 5 documented cases of autologous cord blood stem cell transplants worldwide to date.
The issue of autologous use is one of intense debate. Autologous stem cell transplantation is well established and used for a variety of haematological and solid tumours. I would draw reference to Gratwohl et al. (2001) who summarised the Haematopoietic stem cell transplantation activity in Europe in 1999. Of 18,720 first transplants 69% (12,841) were autologous (this figure includes 6,289 transplants for leukaemias, 30% autologous; 8,219 transplants for lymphomas, 92% autologous; 3,302 transplants for solid tumours, 99% autologous). This activity has increased substantially over the last few years. The debate is not whether there is a role for autologous progenitor cell transplantation but will cord blood stem cells provide the source of these cells for autologous use in the future. At Cells 4 Life, we believe that as the cohort of patients who have stored cord blood worldwide is followed autologous use of this resource will replace conventional peripheral blood progenitor cell mobilisation procedures and therapies currently available. Unfortunately the cord blood storage programmes are not yet old enough to be releasing samples for this use.
There is another debate with regard to autologous use, which is that for selected blood malignancies the genetic defect is pre-programmed and which would prohibit autologous use as a therapy option. The review by Greaves (2002) referred to a study where 1% of 600 blood samples were positive for the TEL-AML1 fusion gene (a common leukaemogenic marker). This incidence is approximately 100 fold the cumulative risk rate of ALL (with TEL-AML1 gene) and clearly indicates that the conversion of the pre-leukaemic clone to overt disease is low, suggesting multi hits are required for evolution of the disease. The concept of a multi-hit mutative process may mean that in fact there is a role for cord blood stem cells collected at birth, as the subsequent leukaemic changes would not occur until some time after birth
The use of autologous cord blood is only in part the issue as many families choose to privately store their child’s cord blood for potential therapeutic applications for siblings. Examples of this include patients in whom a sibling is awaiting cardiac transplantation where there may be a possible use of the sample as a cellular cardiomyoplasty at some point in the next 5 years. Other examples include diabetic families who are making an informed choice to store their child’s cord blood based on the currently available research evidence for gene therapy based stem cell therapies for diabetes that have shown promising results.Wayne Channon, Director of Cells4Life Ltd, a Stem cell and cord blood storage expert.
http://www.cells4life.co.uk
Article Source: http://www.simplysearch4it.com/article/51972.html
|
|
Motorola M9328MX1ADS Application Development System & M9328MX1LCD LCD Panel 1.1 $659.99 |
|
|
Motorola M9328MX1ADS Application Development System & M9328MX1LCD TFT LCD Panel $649.99 |
|
|
GVISION USA (P17BH-AB-459G) 17″ TFT LCD Monitor POS Application $523.99 |
|
|
CyberPower Smart Application Intelligent LCD 1500VA Rac $375.99 |
|
|
GVISION USA (L15AX-JA-452G) 15″ TFT LCD Monitor POS Application $378.99 |
|
|
GVISION 10.4″ LCD POS APPLICATION SCREEN – 800X600!!!!! $249.95 |
|
|
AUO 15 LCD Panel for Industrial Application G150X1-L01 $180.00 |
|
|
AUO 15 LCD Panel for Industrial Application G150X1-L01 with 90days warranty $178.00 |
|
|
AUO 12.1 TFT LCD module for Industrial Application 800*600 G121SN01 V.4 $120.00 |
|
|
AUO 12.1 TFT LCD module for Industrial Application 800*600 G121SN01 V.4 new $119.00 |
|
|
Digital Flow Meter with LCD display for Water Filter Applications 8000T (16-6) $46.65 |
|
|
4″ Inch LCD TV Raw Screen for 12v Application Universal Use $44.00 |
|
|
Office Depot 412318 Digital Camera LCD Screens/Lens Cleaning Kit 2 Applications $11.39 |
|
|
Marshall V-BP12-LCD 12V Rechargeable Battery for mobile applications $57.99 |
|
|
Fujitsu LifeBook S7211 PCB LCD Application CP362026 $35.00 |
|
|
Extech EX450 True RMS Autoranging Multimeter with Infrared Thermometer $119.99 Compact and powerful, the Extech EX450 Eight-Function True RMS Professional MultiMeter provides the versatility of multiple meters in one convenient device. The EX450 measures AC/DC voltage and current, resistance, diode, and temperature. It also includes a built-in, non-contact infrared thermometer that allows you to detect invisible hot spots, as well as a True RMS function for correcting any di… |
|
|
Adam Equipment WBW Washdown Bench Scale The Adam Equipment WBW is designed for food, agriculture, and other wash down applications. Ideal for food preparation, food processing plants, agricultural facilities, and more, WBW scales feature an IP65 rated wash down housing and a large stainless steel weighing pan. Color indicators for Under, Ok, and Over limits make check weighing fast and easy, and a brilliant backlit LCD with capacity tra… |
|
|
Universal 4.3-inch Screen Protector for Garmin Nuvi $0.01 100 percent brand new, high quality, PET screen protector for Garmin Nuvi 255W, 205W, 265WT, 1300, 1350, 1390T, 1370T, 1350T, 755T, 765T, 775T, 785T, 855, 885T, 465T, Zumo 660, and many more. Designed for daily use, this ultra clear screen protector is quick and easy to apply and it can be removed without leaving residue. One screen protector made from high quality Japanese PET material, one clean… |
|
|
Parrot MKi9200 Advanced Color Display Bluetooth Hands-Free Music Kit $249.99 The MKi system is a unique range of Bluetooth hands%2Dfree car kits which install in every car%2E It combines the latest communication technologies with a full set of services dedicated to music%2E Once paired with your Bluetooth mobile phone%2C the MKi enables you to establish in a few seconds any phone conversations in your vehicle without needing to handle the telephone%2C even leaving it in yo… |
|
|
Sony CDXM60UI Marine CD Receiver MP3/WMA/AAC Player with USB Wire for iPod and USB Devices (White/Silver) $199.95 52W x4 High Power : Detachable Faceplate with Front Panel Aux In & AUX cap : Rear USB Wire for iPod and other USB devices (1.5 m cable included) : Quick-BrowZer with Jump Mode and Zappin : Passenger Control with Display Function : MP3/WMA/AAC playback1 with DM+ : UV resistant paint : Conformal circuit board coating : EQ3 Stage 2, DSO2 : SAT Radio ready / HD Radio ready : Front, Rear/Sub … |
|
|
Nintendo 3DS – Cosmo Black $152.50 Introducing the Nintendo 3DS system. Experience incredible gameplay featuring real 3D graphics, with no need for special glasses. Nintendo 3DS is a breakthrough in portable entertainment, a truly cutting-edge piece of hardware. It has to be seen to be believed. Product Type: Handheld Game Console Processor & Chipset Processor Manufacturer: ARM Standard Memor… |
|
|
Nintendo 3DS Screen Protective Filter $6.12 3DS SCREEN PROTECTIVE FILTER… |
|
|
2 Piece LCD Screen Protector Film for New Nintendo DSi $0.01 2 Piece LCD Screen Protector Film for New Nintendo DSi… |
|
|
InFocus X2 Multimedia DLP Projector $699.99 Amazon.com Product Description If you’re in the market for a cost-effective digital projector that can shine during your workdays for presentations or classroom use and moonlight on weekends as part of your home theater experience, you’ll want to take a close look at the InFocus X2 Multimedia DLP Projector. Featuring a 4:3 format DLP chip in 800 x 600 resolution, a four-segment, 2x speed color whe… |
|
|
Tripp Lite SR42UB 42U Rack Enclosure Server Cabinet $1,704.60 Product Type: Rack CabiForm Factor: 19″ 42UDimensions: 78.50″ Height x 23.63″ Width x 43″ DepthPackage Contents: SmartRack SR42UB Premium 42U Standard Rack Enclosure with Doors and Side PanelsStandard Warranty: 5 Year… |
